Reference Viruses for Use in Amantadine Sensitivity Testing of Human Influenza A Viruses

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Population

Influenza A virus strains

Comparison

Selection of a new reference strain sensitive to… vs Previously used reference strains

Design

Preclinical

Authors

Discussion

May enhance lab safety for amantadine sensitivity testing; leaves open validation beyond this animal study.

Population

Influenza A virus strains

Intervention

Selection of a new reference strain sensitive to amantadine and derivation of a resistant mutant

Comparator

Previously used reference strains (potential human pathogens)

Outcome

Safety for use as internal controls in diagnostic and research laboratories

New, safer reference strains of influenza A virus have been selected for amantadine sensitivity testing in laboratories.

Alan P. Kendal (1991) studied this question.

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