What question did this study set out to answer?

Investigate the clinical and haematological relationship between Raynaud's phenomenon, chronic haemolytic anaemia, and the production of cold-reactive antibodies.

July 1, 1951QJM

The Association of Raynaud's Phenomena, Chronic Haemolytic Anaemia, and the Formation of Cold Antibodies

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Authors

DFDavid FerrimanNorth Middlesex Hospital JDJ. V. DacieTufts University KKK. D. KEELEMiddlesex Hospital

Discussion

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Implication

Clinical report demonstrates an association between Raynaud's phenomenon, chronic haemolytic anaemia, and cold antibodies, highlighting cold agglutinin-mediated erythrocyte destruction.

Key Points

Investigate the clinical and haematological relationship between Raynaud's phenomenon, chronic haemolytic anaemia, and the production of cold-reactive antibodies.
Evaluated clinical cases presenting with co-occurring peripheral vasospasm and persistent anaemia.
Characterized serological activity of cold agglutinins and measured indices of red blood cell destruction.
Identifies a direct association between cold-induced acrocyanosis, accelerated intravascular erythrocyte breakdown, and high-titre cold antibodies.
Demonstrates that low-temperature autoantibodies drive microvascular clumping in extremities alongside chronic haemolysis.

Cite This Study

Ferriman et al. (1951) studied this question.

synapsesocial.com/papers/6a903e2b7b6e700e2c8a4798 https://doi.org/10.1093/oxfordjournals.qjmed.a066619

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Implication

Clinical report demonstrates an association between Raynaud's phenomenon, chronic haemolytic anaemia, and cold antibodies, highlighting cold agglutinin-mediated erythrocyte destruction.

The Association of Raynaud's Phenomena, Chronic Haemolytic Anaemia, and the Formation of Cold Antibodies

Discussion

Member takes

Implication

Key Points

Cite This Study

The Association of Raynaud's Phenomena, Chronic Haemolytic Anaemia, and the Formation of Cold Antibodies

Discussion

Member takes

Implication

Key Points

Cite This Study

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