Why the study?
Does the exercise test detect abnormal muscle membrane excitability in patients with muscle channelopathies compared to normal controls?
Population
64 patients with different muscle disorders and 46 normal controls
Comparison
Exercise test consisting of a 5-min maximal… vs 46 normal controls
Design
Case-control
Key result
The exercise test demonstrated a mean sensitivity of 63% for detecting abnormal muscle membrane excitability in patients with ion channel muscle disorders.
Authors
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The exercise test is a useful tool for confirming abnormal muscle membrane excitability in patients with calcium and sodium channelopathies and thyrotoxic periodic paralysis.
Case-Control (n=110)
Does the exercise test detect abnormal muscle membrane excitability in patients with muscle channelopathies compared to normal controls?
The exercise test is a useful tool for confirming abnormal muscle membrane excitability in patients with calcium and sodium channelopathies and thyrotoxic periodic paralysis.
Küntzer et al. (2000) conducted a case-control in Muscle channelopathies and other muscle disorders (n=110). Exercise test (5-min maximal contraction) vs. Normal controls was evaluated on Percentage change in compound muscle action potential (CMAP) amplitude and area (test sensitivity). The exercise test demonstrated a mean sensitivity of 63% for detecting abnormal muscle membrane excitability in patients with ion channel muscle disorders.