Why the study?
Does injecting a low constant sinusoidal current provide a practically equivalent estimate of transventricular impedance compared to using the time constant of an exponential defibrillatory discharge in a canine model of fibrillation?
Does injecting a low constant sinusoidal current provide a practically equivalent estimate of transventricular impedance compared to using the time constant of an exponential defibrillatory discharge in a canine model of fibrillation?
Injecting a low constant sinusoidal current is a practical and easy method to estimate transventricular impedance during fibrillation, yielding results comparable to using the time constant of a defibrillatory discharge.
Low-current sinusoidal impedance measurement is hypothesis-generating in canine VF; leaves open human translation and clinical validation.
Transventricular impedance during fibrillation was measured with two methods: 1) by injecting a low constant sinusoidal current (obtaining a Z value), and 2) by using the time constant of an exponential defibrillatory discharge (giving an R value). One group of eight dols (Group 300) was normothermic and another group of 14 dogs (Group 400) was hypothermic. The left anterior descending coronary artery was ligated in both groups. For Group 300 (values in ohms), Z = 29.5 (SD 5.1), R = 30.9 (SD 4.7). The paired t-test gave a statistically significant difference (p 0.1 percent). For Group 400, Z = 34.5 (SD 7.3); R = 33.8 (SD 5.8), also with a significant difference, but at a lower level (p 5 percent). Nonetheless, from the practical point of view of calculating the voltage to be applied after establishing an adequate dose current, they (the differences) do not seem to have any important quantitative weight, supporting method 1 (for its easiness) to estimate transventricular impedance in this particular application.
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Savino et al. (1983) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: