Watson & Marrian (1955) detected the presence in extracts of the urine of pregnant women of a ketonic Kober chromogen which was more 'polar' than oestrone, and, on solvent-partition evidence, concluded that it was 16-oxo-oestradiol-17P (16-oxo-oestra-1:3:5-triene-3:17,B-diol).More recently Marrian, Watson & Panattoni (1957) concentrated this Kober chromogen (KC-5) and showed conclusively that the major component in it must have been either 16m-hydroxyoestrone (17- oxo-oestra-1:3:5-triene-3:160-diol) or 16p-hydroxyoestrone (17-oxo-oestra-1 :3:5-triene-3: 16,B-diol), and not 16-oxo-oestradiol-17,.On biogenetic grounds the view was favoured that the major component in KC-5 was 16m-hydroxyoestrone rather than 16phydroxyoestrone, but since reduction with sodium borohydride yielded a mixture of oestriol (oestra- 1: 3: 5-triene-3: 16cx: 17p-triol) and 16-epioestriol
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Marrian et al. (1957) studied this question.