Why the study?
Does combined anticoagulant and anti-fibrinolytic prophylaxis reduce postoperative thromboembolic complications in patients undergoing prostatectomy?
Does combined anticoagulant and anti-fibrinolytic prophylaxis reduce postoperative thromboembolic complications in patients undergoing prostatectomy?
Combined anticoagulant and anti-fibrinolytic prophylaxis reduces thromboembolic complications without increasing bleeding risk during prostatectomy.
May support combined prophylaxis to reduce thromboembolic events after prostatectomy without excess bleeding; leaves open confirmation in RCTs.
In 100 consecutive cases of prostatic hypertrophy, prostatectomy was performed during anticoagulant prophylaxis with dicumarol or marcoumar. Anti-fibrinolytic prophylaxis with epsilon-aminocaproic acid (E-ACA) was given simultaneously during and after the operation. The incidence of postoperative thromboembolic complications was significantly reduced as compared with that in 100 controls who did not receive the prophylactic medication. Anticoagulant prophylaxis does not increase the blood loss during or after prostatectomy if it is combined with E-ACA.
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O Storm (1967) studied this question.
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