August 24, 2010TrialsOpen Access

Study design and rationale of 'Influence of Cilostazol-based triple anti-platelet therapy on ischemic complication after drug-eluting stent implantation (CILON-T)' study: A multicenter randomized trial evaluating the efficacy of Cilostazol on ischemic vascular complications after drug-eluting stent implantation for coronary heart disease

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Why the study?

Does triple anti-platelet therapy (aspirin, clopidogrel, and cilostazol) reduce 6-month major adverse cardiovascular and cerebrovascular events compared to dual anti-platelet therapy in patients receiving percutaneous coronary intervention with drug-eluting stents?

Structured PICO

Population

960 patients at least 18 years of age with typical ischemic symptoms or positive stress test and a native coronary lesion (≥50% diameter stenosis by visual estimation and reference diameter ≥2.5 mm) receiving percutaneous coronary intervention with drug-eluting stent for coronary heart disease in Korea.

Intervention

Triple anti-platelet therapy (cilostazol 200 mg loading dose immediately before procedure, then maintenance added to aspirin and clopidogrel) for 6 months, randomly stratified to receive either atorvastatin 20 mg or rosuvastatin 10 mg daily indefinitely.

Comparator

Dual anti-platelet therapy (aspirin and clopidogrel) for 6 months, randomly stratified to receive either atorvastatin 20 mg or rosuvastatin 10 mg daily indefinitely.

Outcome

Composite of cardiac death, nonfatal myocardial infarction, target lesion revascularization, and ischemic stroke at 6 months.composite

The CILON-T trial is designed to determine whether adding cilostazol to dual anti-platelet therapy reduces ischemic events and platelet reactivity in real-world patients undergoing PCI with drug-eluting stents.

Discussion

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Implication

Will inform triple antiplatelet use after DES-PCI; RCT extends evidence on cilostazol for ischemic events and reactivity.

Cite This Study

Lee et al. (2010) studied this question.

synapsesocial.com/papers/6a9047adfdaee66aea8408cf https://doi.org/10.1186/1745-6215-11-87

Topics

Dual antiplatelet therapy Statin therapy

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Structured PICO

Discussion

Implication

Cite This Study

Topics

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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