Key result
Lower levels of HDL-C were most closely correlated with an increased number of significantly stenosed coronary vessels on MDCT (P=0.0014), independent of other metabolic markers.
Why the study?
Does lower HDL-C predict coronary artery stenosis on MDCT in outpatients suspected to have CAD or with at least 1 cardiac risk factor?
Cross-Sectional (n=313)
No
Does lower HDL-C predict coronary artery stenosis on MDCT in outpatients suspected to have CAD or with at least 1 cardiac risk factor?
Lower levels of HDL-C may be the most useful metabolic factor for predicting coronary artery disease severity on MDCT, independent of adiponectin or visceral fat area.
May aid CAD severity stratification on MDCT; leaves open causal role and need for prospective outcome trials.
BACKGROUND: The association between metabolic syndrome (MetS) and the severity of coronary artery disease (CAD) as determined by multidetector row computed tomography (MDCT) is unclear. METHODS AND RESULTS: The number of significantly stenosed vessels (VD), coronary artery calcification score, visceral fat area (VFA), subcutaneous fat area (SFA), and abdominal circumference were quantified using MDCT. Plasma levels of metabolic factors were also measured. Plasma levels of adiponectin were negatively correlated with body mass index, diastolic blood pressure, triglycerides, hemoglobin A(1c), fasting glucose, SFA, VFA and waist circumference, and positively correlated with age and high-density lipoprotein-cholesterol (HDL-C). VD in the MetS group was significantly higher than in the non-MetS group. In the 5 groups classified according to the number of metabolic factors, adiponectin was significantly decreased, whereas VD was significantly increased as the number of factors increased. Multivariate logistic regression analysis revealed that the number of VD was most closely correlated with HDL-C (P=0.0014). CONCLUSIONS: Of the metabolic factors, lower levels of HDL-C may be most useful for predicting CAD independent of other metabolic markers such as adiponectin, VFA or present medication.
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Mitsutake et al. (2008) conducted a cross-sectional in Suspected coronary artery disease or cardiac risk factors (n=313). Metabolic factors (specifically HDL-C) vs. Higher HDL-C levels was evaluated on Number of significantly stenosed vessels (VD) on MDCT (p=0.0014). Lower levels of HDL-C were most closely correlated with an increased number of significantly stenosed coronary vessels on MDCT (P=0.0014), independent of other metabolic markers.
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