Key result
Two weeks of daily inhaled budesonide (1.6 mg/day) increased muscle Na+,K+ATPase content by 17% (P≤0.01) but did not improve high-intensity cycling endurance in healthy men.
Why the study?
Does 2-week inhalation of budesonide increase muscle Na,K ATPase content and endurance in response to terbutaline in healthy trained men?
Does 2-week inhalation of budesonide increase muscle Na,K ATPase content and endurance in response to terbutaline in healthy trained men?
Mean Difference: 46
p-value: p=≤ 0.01
Therapeutic inhalation of budesonide increases muscle Na,K ATPase content but does not enhance high-intensity cycling endurance in response to terbutaline.
No endurance benefit despite Na,K-ATPase upregulation cautions athletes against performance claims; leaves open effects in clinical populations.
While chronic systemic administration of glucocorticoids increases muscle Na+,K+ATPase content, such effect is unexplored after therapeutic inhalation. We investigated the effect of therapeutic inhalation of the glucocorticoid budesonide on Na+,K+ATPase content of skeletal muscle in men. Ten healthy trained subjects, aged 23 ± 4 years (mean ± 95%CI), participated in the study. Before and after 2 weeks of daily inhalation of budesonide (1.6 mg/day), a biopsy was taken from the vastus lateralis muscle for measurement of Na+,K+ATPase content and blood samples were drawn for determination of plasma budesonide, cortisol, and K+. Subjects' performance during cycling to fatigue at 90% of incremental peak power output (iPPO) was measured in response to 4 mg inhaled terbutaline to maximally stimulate Na+,K+ATPase activity. Plasma concentrations of budesonide rose to 5.0 ± 1.6 nM with the intervention, whereas no changes were observed in plasma cortisol. Muscle Na+,K+ATPase content increased (P ≤ 0.01) by 46 ± 34 pmol/(g wet wt) (17% increase) with the intervention. Cycling performance at 90% ofiPPOdid not change (P = 0.21) with the intervention (203 vs 214 s) in response to terbutaline. The present observations show that therapeutic inhalation of glucocorticoids increases muscle Na+,K+ATPase content, but does not enhance high‐intensity cycling endurance in response to terbutaline.
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Hostrup et al. (2016) studied Healthy (n=10). Budesonide vs. Baseline was evaluated on Muscle Na+,K+ATPase content (MD 46 pmol/(g wet wt), p=≤ 0.01). Two weeks of daily inhaled budesonide (1.6 mg/day) increased muscle Na+,K+ATPase content by 17% (P≤0.01) but did not improve high-intensity cycling endurance in healthy men.
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