In subjects who abuse amphetamine, the euphoric effect of 200 mg. of D,L‐amphetamine intravenously was reduced or abolished by oral pretreatment with α‐methyl‐p‐tyrosine (α‐MT) 2.0 to 4.0 Gm. The blockade of the amphetamine‐induced euphoria lasted for about 24 hours. After one week of daily administration of α‐MT, there was a reduction of the antiamphetamine effect. Three days after withdrawal, the renewed administration of α‐MT again caused a high degree of blockade of amphetamine‐induced euphoria.
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Jônsson et al. (1971) studied this question.
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