Key result
Acute phase viral myocarditis was associated with significantly lower serum IL-35 levels (16.8 vs 56.3 pg/ml) and CD4+EBI3+ T cell percentages compared to healthy controls, which negatively correlated with cTnI and IL-17 levels.
Case-Control (n=60)
No
Absolute Event Rate: 16.8% vs 56.3%
p-value: p=<0.01
IL-35 and CD4+EBI3+ T cells are significantly reduced in acute viral myocarditis and negatively correlate with myocardial injury (cTnI) and inflammation (IL-17), suggesting a role in disease progression.
Plasma IL-35 and CD4+EBI3+ T-cell changes may mark VMC activity; leaves open biomarker or therapeutic roles pending prospective validation.
Introduction: Viral myocarditis (VMC) has become an increasingly common heart disease that endangers human health. In the present study, the plasma interleukin-35 (IL-35) level and the percentage of CD4+EBI3+ T cells in VMC patients were detected to investigate the significance of changes in these parameters in the plasma of VMC patients and their association with the disease. Material and methods: ELISA was performed to detect the plasma IL-35 level and the percentage of peripheral blood CD4+EBI3+ T cells in 40 VMC patients and in 20 healthy individuals. Moreover, the plasma IL-17 levels in the VMC patients and in the healthy individuals were detected using an ELISA, and the cardiac Troponin-I (cTnI) levels were detected using a chemiluminescent microparticle immunoassay to compare the differences in the groups. Results: Plasma IL-35 level and the percentage of CD4+EBI3+ T cells in acute phase VMC patients was lower than that in the healthy control group and the convalescent phase VMC patients. Additionally, the plasma IL-35 level in the VMC patients exhibited a negative correlation with the levels of cTnI and IL-17. The percentage of CD4+EBI3+ T cells also showed a negative correlation with the levels of cTnI and IL-17. Conclusions: The plasma IL-35 level and the percentage of CD4+EBI3+ T cells in VMC patients was reduced, and the amount of the decrease was associated with the severity of the disease. These results suggest that IL-35 and CD4+EBI3+ T might play important roles in the progression of VMC and could be used as indictors of the disease.
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Ouyang et al. (2017) conducted a case-control in Viral myocarditis (n=60). Viral myocarditis vs. Healthy individuals was evaluated on Serum IL-35 levels (pg/ml) (p=<0.01). Acute phase viral myocarditis was associated with significantly lower serum IL-35 levels (16.8 vs 56.3 pg/ml) and CD4+EBI3+ T cell percentages compared to healthy controls, which negatively correlated with cTnI and IL-17 levels.
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