SummaryDextran released histamine in a selective manner from suspensions of normal rat peritoneal mast cells. Some characteristics of the release reaction are described. The quantity of histamine released by dextran was reduced about 50% by the presence of isoproterenol (10-8M), epinephrine (10-7M) or norepinephrine (10-6M). Propranolol but not phenoxybenzamine abolished the isoproterenol effect. Prostaglandin E1 (10-5M) also partially inhibited histamine release by dextran. Theophylline and dibutyryl cyclic AMP also produced a dose-related inhibition of the release, which reached 50% effectiveness at about 2 × 10-4M concentration. Effects of several miscellaneous drugs are also described. The results obtained with the principal drugs indicated that the release reaction might be modulated by cyclic AMP.I am grateful to Mr. Ronald Adamik for his excellent technical assistance.
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Jeffrey H. Baxter (1972) studied this question.
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