The first asymmetric catalytic synthesis of syn-alk-1-ene-3,4-diols was developed; the regio-, diastereo- and enantioselective addition of 3-chloropropenyl pivaloate to aldehydes was made possible by exploiting Salen–Cr(II) species, in a catalytic version of the Nozaki–Hiyama–Kishi reaction.
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Lombardo et al. (2003) studied this question.