The Relation of Mastocytosis and Lymphomatous Disease

Case Studies1 April 1966The Relation of Mastocytosis and Lymphomatous DiseaseROBERT K. NIXON, M.D., F.A.C.P.ROBERT K. NIXON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-4-856 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe distribution of mast cells and particularly their presence in the marrow of normal and disease states has been subject to controversy. As recently as 1951, Fadem (1) concluded that tissue mast cells were abnormal constituents of human marrow. Subsequent reports (2-6) and our own observations covering several hundred studies in both normal subjects and persons with a wide spectrum of diseases indicate that mast cells are found in limited numbers in normal marrow. The purpose of this report is to emphasize the association of mast cells in increased numbers in small cell lymphocytic disorders and to suggest that rarely...References1. FADEM RS: Tissue mast cells in human bone marrow. Blood 6: 614, 1951. CrossrefMedlineGoogle Scholar2. JOHNSTONE JM: The appearance and significance of tissue mast cells in human bone marrow. J. Clin. Path. 7: 275, 1954. CrossrefMedlineGoogle Scholar3. WILLIAMS GT: Tissue mast cells in human bone marrow. Amer. J. Clin. Path. 22: 1039, 1952. CrossrefMedlineGoogle Scholar4. VIÑALS RR: Celulas cebadas tisulares (heparinocitos) en los organos hematopoyeticos. Folia Clin. Int. (Barc.) 4: 471, 1954. Google Scholar5. ENDECHERNISS JEI: Mast cells, histamine and serotonin: studies of the human spleen. Amer. J. Clin. Path. 30: 35, 1958. CrossrefMedlineGoogle Scholar6. LENNERTSCHUBERT KJC: Zur Histochemie der Gewebsmastzelle im menschlichen Lymphknoten. Frankfurt Z. Path. 69: 591, 1959. Google Scholar7. 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(Leipzig) 8: 504, 1908. Google Scholar15. MICHELS NA: The mast cells, in Handbook of Hematology, vol. 1, by DOWNEY, H. P. B. Hoefer, Inc., New York, 1938, pp. 232-372. Google Scholar16. GINSBURG H: The in vitro differentiation and culture of normal mast cells from the mouse thymus. Ann. N. Y. Acad. Sci. 103: 20, 1963. CrossrefMedlineGoogle Scholar17. DEGOSLORTAT-JACOBHEWITTOSSIPOWSKI REJB: Réticulose â mastocytes, forme cutanée diffuse. Bull. Soc. Franc. Derm. Syph. 59: 247, 1952. MedlineGoogle Scholar18. PAFFBLOOMREILLY GHFC: The morphology and behavior of neoplastic mast cells cultivated in vitro. J. Exp. Med. 86: 117, 1947. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, MichiganFrom the Department of Medicine, Henry Ford Hospital, Detroit, Mich.This paper was presented at the third Fall Meeting of the American College of Physicians, October 8, 1965, Miami Beach, Fla.Requests for reprints should be addressed to Robert K. Nixon, M.D., Henry Ford Hospital, Detroit, Mich. 48202. 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