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November 21, 2008Stroke

Exaggeration of Focal Cerebral Ischemia in Transgenic Mice Carrying Human Renin and Human Angiotensinogen Genes

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Why the study?

Does valsartan reduce ischemic brain damage in transgenic mice carrying human renin and angiotensinogen genes?

Population

Chimeric transgenic mice with human renin and human angiotensinogen genes subjected to permanent occlusion…

Comparison

Valsartan (3.0 mg/kg per day) for 2 weeks vs Untreated hRN/hANG-Tg mice, wild-type mice…

Design

Preclinical

Follow-up

24 hours post-occlusion (after 2 weeks of treatment)

Authors

SIShinji InabaMIMasaru IwaiYTYumiko Tomono

Discussion

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Overview

AT1 blockade mitigates RAS-exaggerated ischemic injury in transgenic mice; extends preclinical data but leaves human translation open.

Structured PICO

Does valsartan reduce ischemic brain damage in transgenic mice carrying human renin and angiotensinogen genes?

P
Population
Chimeric transgenic mice with human renin (hRN) and human angiotensinogen (hANG) genes subjected to permanent occlusion of the middle cerebral artery (MCA)
I
Intervention
Valsartan (3.0 mg/kg per day) for 2 weeks
C
Comparator
Untreated hRN/hANG-Tg mice, wild-type mice, hRN-Tg mice, and hANG-Tg mice
O
Outcome
Ischemic brain area at 24 hours after MCA occlusionsurrogate

Activation of the human renin-angiotensin system exaggerates ischemic brain damage, which can be mitigated by AT1 receptor blockade with valsartan.

Cite This Study

Inaba et al. (2008) studied this question.

synapsesocial.com/papers/6a90506aa9ec819f9b2da3a3https://doi.org/10.1161/strokeaha.108.519801
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