Summary. The activation of bovine plasma factor IX requires activated factor XI and calcium ions, but not phospholipids. It results in an apparent reduction in molecular size or shape as shown by gel filtration on Sephadex G‐200 and sucrose gradient ultracentrifugation. DEAE chromatography reveals that the surface charge may be altered upon activation. In the presence of calcium ions, both the precursor and activated form of factor IX showed reduction in sizes. Calcium ions also promote the adsorption of factor IXa on a glass surface. The significance of the change of size and surface charge in the interaction of factor IX and phospholipids is discussed.
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Chuang et al. (1974) studied this question.
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