Fitting five into six: The crystal structure of a glycosidase-bound, five-membered iminocyclitol inhibitor was determined (see picture), and its binding interactions were compared to those of the classical six-membered iminocyclitol inhibitors isofagomine and glucoimidazole and of the glycosyl–enzyme intermediate. This information may be used to develop more potent and specific therapeutically useful glycosidase inhibitors.
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Caines et al. (2007) studied this question.
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