Giant follicular lymphoblastoma of the rectum (brill-symmers disease)

Summary and Conclusions The authors have presented a case of giant follicular lymphoblastoma (Brill-Symmers disease) involving the rectum. It is a rare disease which pursues a fairly characteristic clinical course. The lesion can be discovered by proctoscopic examination but, to establish the differential diagnosis, microscopic examination is essential. Biopsy should not be relied upon: the entire lesion should be available for microscopic study. Eventually, the lesion may become malignant. Specific treatment consists of complete removal of the tumor by surgical operation; subsequently, irradiation should be administered to destroy residual cells.