Tricinonoic acid and tricindiol, two new irregular sesquiterpenes from an endophytic strain ofFusarium tricinctum

Bharat P. Bashyala & A.A. Leslie Gunatilakaa* a Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences , The University of Arizona , 250 E. Valencia Road, Tucson , AZ 85706-6800 , USA * E-mail: leslieg@ag.arizona.edu Two new rare irregular sesquiterpenes, tricinonoic acid (1) and tricindiol (2), and the known furanopyrrolidones, NG-391 (3) and NG-393 (4), have been isolated from an EtOAc extract of Fusarium tricinctum, a fungus endophytic in the root tissue of the Sonoran desert plant, Rumex hymenosepalus. The structures of 1 and 2 were elucidated on the basis of their high-resolution mass, 1D and 2D NMR spectroscopic data. A possible biosynthetic route to 1 and 2 from farnesyl diphosphate is proposed.