Population
Drosophila melanogaster and Caenorhabditis elegans models
Comparison
Genetic mutation/loss of kettin activity vs Wild-type (normal kettin activity)
Design
Preclinical
Authors
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Kettin loss impairs Drosophila muscle function; extends sarcomere biology in model systems but leaves human relevance open.
Kettin is a highly conserved giant muscle protein essential for sarcomere structure, viability, and muscle function in Drosophila.
Hakeda‐Suzuki et al. (2000) studied this question.
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