Summary:Coinage metal salts (e.g. AuIII, AgI and CuII salts) readily react with thiols to give the corresponding metal(I) thiolates. These thiolate species are known to either self‐assemble into insoluble polymeric species or to form soluble oligomers, depending on the nature of the thiol ligand. Here we demonstrate that this self‐assembling ability can be applied to create supramolecular hydrogels. Glutathione (GSH), a naturally occurring tripeptide, has been used in combination with AuIII, AgI and CuII salts to obtain pH responsive hydrogels that are able to gelate 100 times their weight in water.
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Odriozola et al. (2008) studied this question.
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