Key result
Titin is a giant filamentous protein spanning half of the muscle sarcomere, functioning as the third filament of muscle alongside thick-myosin and thin-actin filaments.
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Design
Review
Titin's role as third filament is hypothesis-generating; leaves open targeted therapies in TTN cardiomyopathies pending higher-level evidence.
Titin - the largest protein in the human body - spans half of the muscle sarcomere from the Z-disk to the M-band through a single polypeptide chain. More than 30 000 amino acid residues coded from a single gene (TTN, in humans Q8WZ42) form a long filamentous protein organized in individual globular domains concatenated in tandem. Owing to its location and close interaction with the other muscle filaments, titin is considered the third filament of muscle, after the thick-myosin and the thin-actin filaments.
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Jaime Andrés Rivas‐Pardo (2018) reported a review. Titin is a giant filamentous protein spanning half of the muscle sarcomere, functioning as the third filament of muscle alongside thick-myosin and thin-actin filaments.
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