The first asymmetric Mannich-type reaction of stabilized phosphorus ylides and N -Boc aldimines was described promoted by a readily available and recyclable chiral bisthiourea organocatalyst. Subsequent reaction with formalin smoothly provides N -Boc-β-amino-α-methylene carboxylic esters in a highly enantiomerically enriched form (up to 96% ee).
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2008) studied this question.