A study of nucleo-cytoplasmic interactions in pre-embryonic development, at maturation stages in particular, is of great interest. During this period ooplasmic segregation takes place, specific properties of the cortex arise, and the cytoplasm obtains information from the oöcyte nucleus which promotes the development of the embryo during all the changes related to fertilization, cleavage and blastulation (Wilson, 1925; Raven, 1961; Brachet, 1957, 1960; Briggs & King, 1959; Neyfakh, 1962).
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Nikitina et al. (1964) studied this question.
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