Facile, selective, and organic: Acid–base organocatalyzed aza-Morita–Baylis–Hillman/aza-Michael domino reactions of α,β-unsaturated carbonyl compounds 1 with N-tosylimines 2 have been developed. The enantioselective process produces the highly functionalized isoindoline as a single diastereomer (Ts=4-toluenesulfonyl).
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Takizawa et al. (2010) studied this question.
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