Why the study?
The study was conducted to evaluate changes in adipocytokines in patients with alcoholic liver cirrhosis associated with non-alcoholic fatty liver disease according to the stage of decompensation.
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Patients with alcoholic liver cirrhosis and NAFLD exhibit significant insulin resistance and altered adipocytokine profiles depending on the stage of decompensation.
The purpose of the research was to study the changes in adipocytokines in patients with alcoholic liver cirrhosis (ALC) associated with non- alcoholic fatty liver disease (NAFLD) depending on the stage of decompensation. A significant increase in immunoreactive insulin, the HOMA-IR index and a decrease in the QUICKI index in patients II gr. in comparison with patients I gr. has been detected, that indicating insulin resistance (p<0.05). On the basis of the results of the analysis of the correlation between the levels of leptin, adiponectin, resistin and carbohydrate metabolism, it was found that a stronger correlation was observed in patients suffering from ALC associated with NAFLD.
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Matkovska et al. (2019) studied this question.
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