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December 16, 2014Organic Chemistry Frontiers

Novel strategies for catalytic asymmetric synthesis of C1-chiral 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydrotetrahydroisoquinolines

Wangsheng Liu Shasha Liu Ruiwen Jin Hao Guo Jinbo Zhao

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Abstract

This review summarizes recent progress in catalytic asymmetric construction of 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydroisoquinolines, among the most important “privileged scaffolds”.

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Cite This Study

Liu et al. (2014) studied this question.

synapsesocial.com/papers/6a905c5ba9a6d70ff18a4e06 https://doi.org/10.1039/c4qo00294f

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Chemistry and Biology of the Tetrahydroisoquinoline Antitumor AntibioticsOriginal Research · 2002 · 1,150 citations
2Design and Synthesis of a Tetrahydroisoquinoline‐Based Hydroxamate Derivative (<scp>ZYJ</scp>‐34v), An Oral Active Histone Deacetylase Inhibitor with Potent Antitumor ActivityIn Vitro Study · 2013 · 6 citations
3Controlling stereoselectivity by enzymatic and chemical means to access enantiomerically pure (1S,3R)-1-benzyl-2,3-dimethyl-1,2,3,4-tetrahydroisoquinoline derivativesOriginal Research · 2013 · 8 citations
4Discovery of Tetrahydroisoquinoline-Based CXCR4 AntagonistsOriginal Research · 2013 · 65 citations
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