A new twist of RNA fate: Site-selective chemical functionalization at the C2′′OH group of paromomycin (1) afforded a novel analogue with potent inhibitory activity against several bacterial strains, including a multidrug-resistant S. aureus (MRSA) strain. X-ray cocrystal-structure determination of the complex with the A site of E. coli RNA revealed a new mode of binding in which significant conformational and positional changes had taken place in rings III and IV.
No takes yet. Share an insight, caveat, or question.
François et al. (2004) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: