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Twenty milligrams of the opiate receptor antagonist naloxone were infused over 3 h to five young male volunteers. Naloxone produced a significant rise in both LH and FSH, but did not affect serum prolactin levels. The infusion of dopamine (4 microgram . kg-1 . min-1) completely abolished the naloxone effect on gonadotrophin release. The results suggest a possible interaction between dopamine, opioid receptors and gonadotrophin secretion in man.
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Delitala et al. (1980) studied this question.
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