Reports a rare case of lymphoplasmacyte-rich meningioma in a child presenting with seizures and systemic inflammatory abnormalities.
Rare lymphoplasmacyte-rich meningioma with systemic inflammation in a child merits diagnostic consideration; extends phenotypic spectrum but leaves open causal mechanisms.
A rare case of lymphoplasmacyte-rich meningioma observed in a young girl is reported. The first clinical manifestations of the disease were seizures. Neuroradiological images favored the existence of a meningioma. Abnormalities in the patient's blood chemistry, principally including hypergammaglobulinemia and inflammatory syndrome, were associated with the disease. The tumor was histologically confirmed as meningioma with massive infiltrates of type B lymphocytes. The pathophysiology of the conspicuous lymphoplasmacyte infiltrates, responsible for peripheral blood abnormalities, has remained poorly understood. Alternative diagnostic hypotheses of masses that mimic this type of meningioma are discussed.
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Loiseau et al. (1995) studied this question.
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