Localization of Injected Bone Marrow Cells by Autoradiography

The distribution of labeled bone marrow cells injected into recipients has been observed by use of autoradiography. Many of the intravenously injected bone marrow cells were removed from circulation by the lungs, although other cells went to various sites such as the bone marrow, spleen, and thymus. Many of the injected, labeled cells found in the hemstopoietic organs were metamyelocytes, although younger forms as well as mature polymnorphonuclear leukocytes were also present. Some types of the injected, labeled cells were not found in the recipients; they may have been rapid destroyed or may have quickly lost their label by rapid turnover of the labeled amino acid. (auth)