December 1, 1999Journal of Biological ChemistryOpen Access

Synergistic Roles of Neuregulin-1 and Insulin-like Growth Factor-I in Activation of the Phosphatidylinositol 3-Kinase Pathway and Cardiac Chamber Morphogenesis

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Structured PICO

Population

Whole mouse embryo culture system and cultured cardiomyocytes

Intervention

Combined treatment with neuregulin-1 and insulin-like growth factor-I

Comparator

Neuregulin-1 alone, insulin-like growth factor-I alone, or pathway inhibitors (wortmannin, dominant negative Rac1)

Outcome

Cardiac chamber morphogenesis, trabeculation, and DNA synthesis of cardiomyocytessurrogate

Combined neuregulin-1 and insulin-like growth factor-I synergistically promote cardiac chamber morphogenesis via the phosphatidylinositol 3-kinase pathway.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

No immediate clinical implications; leaves open neuregulin-1/IGF-I synergy for cardiac regeneration research.

Cite This Study

Hertig et al. (1999) studied this question.

synapsesocial.com/papers/6a9068c3fecd36257390addb https://doi.org/10.1074/jbc.274.52.37362

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Synergistic Roles of Neuregulin-1 and Insulin-like Growth Factor-I in Activation of the Phosphatidylinositol 3-Kinase Pathway and Cardiac Chamber Morphogenesis

Structured PICO

Discussion

Implication

Cite This Study

Synergistic Roles of Neuregulin-1 and Insulin-like Growth Factor-I in Activation of the Phosphatidylinositol 3-Kinase Pathway and Cardiac Chamber Morphogenesis

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider