Agelenin is a neurotoxic peptide previously isolated from the venom of a spider, Agelena opulenra, and consists of 35 amino acid residues. In the present study, the carboxyl terminus of agelenin was found to be amide form but not carboxylic acid form by dansyl-Edman degradation-analysis as well as by peptide synthesis. Among six cysteine (Cys) residues in agelenin, formation of disulfide bond between Cysm and Cys" was determined. As for the rest of Cys residues two possible arrangements of disulfide bonds were Cys3-Cysig and Cyslg-Cys34, or Cys3-Cys19 and Cyslg-Cys3'*.
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Hagiwara et al. (1991) studied this question.