An intensity function combining peak intensities in the same manner as that in which equilibrium constants combine ion activities is suggested for chracterization of enantioselectivity by fast-atom bombardment mass spectrometry. The intensity function combined with the use of two internal standards, one similar to the host, one to the guest compounds is shown to give excellent results: The enantioselectivity is better by up to factor of 10 than that obtained using one internal standard only, and its reproducibility is ca. a factor of 10 better, than that obtained using relative peak intensitities (the RPI method).
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Dobó et al. (1997) studied this question.