Echovirus 18 infection in young children can frequently present with aseptic meningitis, which carries a notable case-fatality rate.
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Echovirus 18 meningitis in young children warrants clinical vigilance; leaves open need for larger cohorts before guiding practice.
Eighty cases of echovirus 18 infection among young children during an outbreak in 2006 in Taiwan were enrolled. Twenty percent of the patients had a comorbid condition. Twenty-five cases (31%) were complicated by aseptic meningitis. The most frequent diagnoses in children without meningitis were pharyngitis/tonsillitis (35%) and vesicular viral exanthem (33%). The case-fatality rate among the children with meningitis was 4%. Echovirus 18 was isolated from the cerebrospinal fluid of 68% of the children.
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Wang et al. (2010) studied this question.
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