A STUDY of immunological factors associated I with resistance to infection in patients with chronic lymphatic leukernia,le it was found that the only laboratory determination that distinguished patients with frequent infectious complications was the level of gamma globulin and that, in general, antibody response is poor in this group.In addition to the laboratory studies, there are relevant clinical factors: the relation of infection to the course of the disease; the types of infection encountered; the relation of infection to the level of gamma globulin; the influence of therapy on the level of gamma globulin; and the results of therapeutic and prophylactic use of gamma globulin.There are also pathological features of interest: the anatomic distribution of the leukemia, the microscopic appearance of the cells of the lymphoid and reticuloendothelial system, and the morphology of the inflammatory response to infection.This paper presents a detailed study of these points in 11 patients with chronic lymphatic leukemia whose From the Lymphoma and Clinical Evaluation sections
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Miller et al. (1962) studied this question.
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