Diabetes Mellitus and Interferon-α Therapy

Letters15 August 1995Diabetes Mellitus and Interferon-α TherapyMasami Murakami, Tokuji Iriuchijima, and Masatomo MoriMasami MurakamiGunma University School of Medicine; Maebashi 371; Japan, Tokuji IriuchijimaGunma University School of Medicine; Maebashi 371; Japan, and Masatomo MoriGunma University School of Medicine; Maebashi 371; JapanAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-4-199508150-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Autoimmune mechanisms are involved in the pathogenesis of type 1 diabetes mellitus [1]. Organ- or non-organ-specific autoimmune events have been reported to occur after interferon therapy [2]. We report a case of type 1 diabetes mellitus associated with ketoacidosis during interferon-α therapy.A 66-year-old Japanese man (body mass index, 24.2 kg/m2) had a left nephrectomy for renal cell carcinoma on 22 June 1993. He had no overt or family history of diabetes mellitus. One month earlier, his fasting and postprandial blood glucose levels were 5.7 mmol/L and 6.5 mmol/L, respectively. He began receiving interferon-α, 5 MU 3 ...References1. Eisenbarth GS. Type 1 diabetes mellitus: a chronic autoimmune disease. N Engl J Med. 1986; 314:1360-8. Google Scholar2. Mayet WJ, Hess G, Gerken G, Rossol S, Voth R, Manns M, et al. Treatment of chronic type B hepatitis with recombinant α-interferon induces autoantibodies not specific for autoimmune chronic hepatitis. Hepatology. 1989; 10:24-8. Google Scholar3. Fabris P, Betterle C, Floreani A, Greggio NA, Lazzari F, Naccarato R, et al. Development of type 1 diabetes mellitus during interferon-alfa therapy for chronic HCV hepatitis. Lancet. 1992; 340:548. Google Scholar4. Stewart TA, Hultgren B, Huang X, Pitts-Meek S, Hully J, MacLachlan NJ. Induction of type I diabetes by interferon-α in transgenic mice. Science. 1993; 260:1942-6. Google Scholar5. Palmer JP, Asplin CM, Clemons P, Lyen K, Tatpati O, Raghu PK, et al. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science. 1983; 222:1337-9. Google Scholar Author, Article, and Disclosure InformationAuthors: Masami Murakami; Tokuji Iriuchijima; Masatomo MoriAffiliations: Gunma University School of Medicine; Maebashi 371; Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInterferon alfaDrug-Induced Endocrine AutoimmunityAssociation of pancreatic autoantibodies and human leukocyte antigen haplotypes with resolution of diabetes mellitus after therapy for hepatitis C virus infection in patients with HIV infection: case report and review of literatureAcute Exacerbation of Diabetes and Hypothyroidism in a Patient With Hepatitis C After Therapy With Interferon AlphaTratamiento con interferón alfa y desarrollo de diabetes mellitus tipo 1Endocrine autoantibodiesPotential Mechanisms of Interferon-α Induced AutoimmunityType 1 diabetes mellitus in patients with chronic hepatitis C before and after interferon therapy17. Immunologic endocrine disordersExpression of endocrine autoantibodies in chronic hepatitis C, before and after interferon-α therapyVaccines and the risk of insulin-dependent diabetes (IDDM): potential mechanism of actionFulminant autoimmune Type 1 diabetes during interferon-alpha therapy: a case of Th1-mediated disease?Diabetic Ketoacidosis Induced by Alpha Interferon and Ribavirin Treatment in A Patient With Hepatitis CThe Endocrine Effects of Nonhormonal Antineoplastic TherapyInsulin-dependent diabetes mellitus during alpha-interferon therapy for chronic viral hepatitisDrugs acting on the immune systemInterferon-?? 15 August 1995Volume 123, Issue 4Page: 318KeywordsAcetonesAutoantibodiesBloodDiabetes mellitusGlucoseHemoglobinInsulinPathogenesisRenal cell carcinomaType 1 diabetes ePublished: 15 August 2000 Issue Published: 15 August 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...