December 1, 1956JAMA
Immunization of Infants With Living Attenuated Poliomyelitis Virus
Why the study?
Does oral administration of living attenuated poliomyelitis virus safely induce active immunity in infants?
Population
24 bottle-fed infants, including some less than a month old
Design
Case_series
Authors
Discussion
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Implication
Hypothesis-generating for early oral polio immunization in neonates; larger controlled trials needed before any practice change.
Structured PICO
Does oral administration of living attenuated poliomyelitis virus safely induce active immunity in infants?
P
Population
24 bottle-fed infants, including some less than a month old
I
Intervention
Living attenuated poliomyelitis virus (SM strain type 1, TN strain type 2, or both) administered orally via formula
O
Outcome
Development of active immunity and asymptomatic alimentary infection (demonstrated by virus isolation from feces)surrogate
Oral administration of living attenuated poliomyelitis virus safely induces active immunity in infants, even those under one month of age or with maternal antibodies.
Cite This Study
Hilary Koprowski (1956) studied this question.