Why the study?
Does oral administration of an attenuated mouse-adapted poliomyelitis virus induce neutralizing antibodies without causing clinical illness in susceptible human subjects?
Does oral administration of an attenuated mouse-adapted poliomyelitis virus induce neutralizing antibodies without causing clinical illness in susceptible human subjects?
Oral administration of an attenuated mouse-adapted poliomyelitis virus safely induced neutralizing antibodies in susceptible human subjects.
Two human subjects who had no antibodies against Type I poliomyelitis virus were fed a mouse adapted Type I strain, and one human subject who had no antibodies against Types I and II was fed a mixture of mouse adapted Type I and Type II strains. None of the individuals showed clinical signs of illness as a result of ingestion of the virus. In the absence of viremia, all 3 excreted virus in the stools. Homologous neutralizing antibodies developed in the sera of each person. Virus passaged through the human intestinal tract maintained the very low pathogenicity for monkeys when injected intracerebrally.
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Koprowski et al. (1954) studied this question.
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