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Animal model shows heterotypic neutralization post-monovalent inoculation; leaves open human vaccine implications.
Summary Rabbits were found to acquire neutralizing capacity for homotypic and heterotypic poliovirus and for ECHO 12 virus following inoculation with a single poliovirus type. The neutralizing capacity for heterotypic and heterologous viruses was shown to have properties of antibody, in that it was produced by antigenic stimulus, was demonstrated in heat-inactivated sera and was not dependent upon the cellular component of the antigen. Rabbits previously immunized with type 2 poliovirus were found to have an enhanced (anamnestic) response to the poliovirus type 1 and 3 components of trivalent vaccine when compared with the control, unsensitized rabbits. Such an anamnestic response was further evidence for the antigenic relationship of of the three poliovirus types.
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Barnett et al. (1961) studied this question.
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