In vitro study demonstrates stable transduction in diverse cell lines, highlighting the therapeutic potential of lymphocytic choriomeningitis virus pseudotypes.
Pseudotyping can improve retroviral vector stability and transduction efficiency. Here, we describe a novel pseudotype of murine leukemia virus packaged with lymphocytic choriomeningitis virus (LCMV). This pseudotype was stable during ultracentrifugation and infected several cell lines from different species. Moreover, LCMV glycoproteins were not cell toxic.
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Miletić et al. (1999) studied this question.
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