Coherent management of thyroid nodules that grow after being identified as benign will vary depending on their biology. Some are thyroid-stimulating hormone (TSH) regulated, so a dose of levothyroxine that reduces TSH to the lower limits of normal (subsuppression) may prevent or reverse enlargement; others are controlled by poorly understood mechanisms that must be elucidated before effective medical treatment can be designed; a few are autonomous requiring obliteration, and a very few are "missed" malignancies that should be excised.
No takes yet. Share an insight, caveat, or question.
Blum et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: