The discovery that mutations in the kelch propeller domain of the K13 gene (PF3D7_1343700) were major determinants of Plasmodium falciparum artemisinin resistance has been validated by several studies in the Mekong region.1–3 The particularity of this discovery is that it took place less than 10 years after the detection of the first clinical cases of artemisinin resistance in western Cambodia and probably before the spread of the mutations to neighbouring malaria-endemic regions and beyond.4 This context is very unique and favours real-time monitoring of artemisinin resistance in endemic areas and anticipation of the risks associated with the emergence and spread of the artemisinin-resistant parasites, a major public health issue.
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Ménard et al. (2015) studied this question.
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