Why the study?
Little is known about how coxsackieviruses cause kidney injury and ESRD or predispose individuals genetically susceptible to type 1 diabetes to kidney injury.
Does Coxsackievirus B4 inoculation cause acute and chronic kidney damage in non-obese diabetic mice without diabetes?
Does Coxsackievirus B4 inoculation cause acute and chronic kidney damage in non-obese diabetic mice without diabetes?
CVB4 exposure in NOD mice induces initial gene expression changes and increased mesangial area in the kidney, suggesting a potential mechanism for viral predisposition to end-stage renal disease in individuals genetically susceptible to type 1 diabetes.
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CVB4 exposure may predispose T1D-susceptible kidneys to mesangial injury; leaves open whether antiviral strategies warrant human investigation.
Walter et al. (2020) studied this question.
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