Extramammary Paget’s Disease: A Case Involving the Prostatic Urethra

A case of Paget’s disease of the prostatic urethra in a 58-year-old Negro man is reported. An underlying carcinoma of the prostate was found in this case and carcinoma was present also in the periurethral prostatic ducts. Paget’s disease of the prostatic urethra has not been reported previously. The histogenetic theories of Paget’s disease are examined in relation to the findings in this case. It seems unlikely that the lesion is a chance occurrence; it is most likely, related to other cases of Paget’s disease of the anogenital region. This relation may develop through the mechanism of a hormone-dependent carcinogenic stimulus. Features in common with mammary and extramammary Paget’s disease, including embryonic origin, are noted and discussed.