Why the study?
Does placental expression of adenosine A2A receptor and HIF-1 alpha differ between normotensive and pre-eclamptic pregnancies?
Does placental expression of adenosine A2A receptor and HIF-1 alpha differ between normotensive and pre-eclamptic pregnancies?
Placental expression of A2AR and HIF-1α is elevated in early pregnancy and pre-eclampsia, suggesting a potential adaptive interaction with the renin-angiotensin system in response to poor placental perfusion.
Hypothesis-generating for A2AR-HIF-1α interaction in early gestation and pre-eclampsia; prospective studies required before clinical relevance.
Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) promote angiogenesis and vascularisation. We investigated the temporal expression placental adenosine A2AR receptor and HIF-1α in early pregnancy and at delivery in normotensive (NT) and pre-eclamptic (PE) women. Results were compared to our previously reported angiotensin receptor data. Expression of A2AR and HIF-1α was highest at ≤10 weeks, positively correlated through pregnancy and was higher in PE than NT at delivery. The A2AR associated with the AT4R only in early pregnancy. We suggest adenosine and RAS may interact to promote placentation with a potential adaptation to poor placental perfusion in PE.
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Kurlak et al. (2015) studied this question.
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