Effect of stereochemistry at the C-17 position on the antifungal activity of pradimicin A.

Pradimicin A (1) is a novel antifungal antibiotic produced by Actinomadura hibisca No. PI57-2 (ATCC 53557)1>2), along with minor components, pradimicins B (2) and C (3)3~5). Pradimicin A (1) wasfound to be active in vitro against a wide variety of fungi and yeasts, and highly effective against systemic fungal infections in mice5'6). Comparative in vitro studies showed that there was no cross-resistance to other antifungal agents and that