Effects of Xanthine Oxidase Inhibitor on Clinical Manifestations and Purine Metabolism in Gout.

s1 April 1964Effects of Xanthine Oxidase Inhibitor on Clinical Manifestations and Purine Metabolism in Gout.R. Wayne Rundles, M.D., F.A.C.P., Harold R. Silberman, M.D., F.A.C.P., George H. Hitchings, Ph.D., Gertrude B. Elion, Ph.D.R. Wayne Rundles, M.D., F.A.C.P.Search for more papers by this author, Harold R. Silberman, M.D., F.A.C.P.Search for more papers by this author, George H. Hitchings, Ph.D.Search for more papers by this author, Gertrude B. Elion, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-717_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA series of pyrazolopyrimidines synthesized some years ago as potential purine antagonists were found to be active in suppressing the growth of bacteria, fungi, tumor cells in culture, and rodent neoplasms. Some of the purine isomers were effective inhibitors of xanthine oxidase in vitro. Two of the most promising compounds, 4-amino- and 4-propylaminopyrazolo (3,4-d)-pyrimidines, were studied clinically as anticancer agents. Their predominant effect was hepatic toxicity.We have found more recently that a major loss in activity of 6-MP and derivatives in man results from oxidative degradation. The possibility of circumventing this by the administration of 4-hydroxypyrazolo (3,4-d)-pyrimidine (HPP), a... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEffect of allopurinol and benzbromarone on the concentration of uridine in plasmaMedikamentöse Beeinflussung von Synthese und Abbau der PurineWahl der Medikamente, Dosierung, ErfolgskontrolleA study of dose-response relationships of allpurinol in the presence of low or high purine turnoverControl of HyperuricemiaDauertherapieUric Acid Metabolism in ManZur Beeinflussung der Purin- und Pyrimidinsynthese durch AllopurinolMechanism of antiuric action of 4-oxy- and 4-thiopyrazolopyrimidinesLitholytic Agents: Preventive and Curative Drugs for NephrolithiasisEffect of allopurinol and oxipurinol on pyrimidine synthesis in cultured human fibroblastsALLOPURINOL AND OXIPURINOL: ALTERATION OF PURINE AND PYRIMIDINE METABOLISM IN CELL CULTURELiver xanthine oxidase in gouty patientsL'Allopurinolo in Urologia(*): Nota 1aSulla Prevenzione Delle Calcolosi Da Acido Urico Con AllopurinoloAn Enzymatic Basis for Variation in Response to AllopurinolAllopurinol Control of Hyperuricosuria: A New Concept in the Prevention of Uric Acid StonesMetabolic and therapeutic effects of allopurinol in patients with leukemia and goutAllopurinol in the Treatment of GoutR. WAYNE RUNDLES, M.D., F.A.C.P., EARL N. METZ, M.D., H. R. SILBERMAN, M.D.Xanthine oxidase inhibitors in the management of goutA New Drug for GoutGoutMetabolic Basis for the Actions of Analogs of Purines and PyrimidinesEffect of allopurinol (4-Hydroxypyrazolo-(3,4-d)pyrimidine) on serum and urinary uric acid in primary and secondary gout 1 April 1964Volume 60, Issue 4Page: 717-718KeywordsBacteriaCell culturesCellsGoutPurine metabolismPurinesToxicity Issue Published: 1 April 1964 PDF DownloadLoading ...