A DNA-origami chip platform for target-labeling-free single-nucleotide polymorphism (SNP) genotyping is presented. DNA capture probes are anchored on an asymmetric map-shaped DNA-origami chip and a “toehold”-mediated strand-displacement reaction is employed to endow single-base-mismatch differentiation specificity. This design leads to a reliable and potentially universal means for SNP genotyping.
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Zhang et al. (2010) studied this question.
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