November 16, 2005Organic Letters

Concise Synthesis of Pochonin A, an HSP90 Inhibitor

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Abstract

[chemical reaction: see text]. An expedient synthesis of (-)-pochonin A is reported (seven steps). This natural product is closely related to radicicol and was shown to be a 90 nM inhibitor of HSP90.

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Moulin et al. (2005) studied this question.

synapsesocial.com/papers/6a9081e77bf96463400d2b47 https://doi.org/10.1021/ol052263+

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Abstract

[chemical reaction: see text]. An expedient synthesis of (-)-pochonin A is reported (seven steps). This natural product is closely related to radicicol and was shown to be a 90 nM inhibitor of HSP90.

Concise Synthesis of Pochonin A, an HSP90 Inhibitor

Abstract

Discussion

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Concise Synthesis of Pochonin A, an HSP90 Inhibitor

Abstract

Discussion

Cite This Study

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